5 Surprising Ozempic Side Effects You Shouldn’t Ignore

Ozempic (semaglutide) has become a well-known name in both diabetes management and weight loss conversations. While it's helped many people lower blood sugar and shed pounds, it’s also important to be aware of its potential risks. Some side effects of Ozempic go far beyond mild nausea or appetite suppression and they deserve your attention.

Here are five serious side effects of Ozempic that many people aren’t aware of, plus what to watch for and when to call your provider.

1. Pancreatitis

Pancreatitis, or inflammation of the pancreas, is a rare but dangerous condition linked to Ozempic. The pancreas plays a crucial role in digestion and blood sugar regulation, and when inflamed, it can cause significant damage to nearby organs.

Symptoms to watch for:

• Sudden or severe abdominal pain, possibly radiating to your back

• Bloating or a distended abdomen

• Fever, nausea, or vomiting

• Shortness of breath

Seek emergency care if you experience these symptoms, as pancreatitis often requires hospitalization, IV fluids, and close monitoring.

2. Gallbladder Problems

Gallbladder issues, including gallstones, have also been reported with Ozempic use. Gallstones can block bile flow and lead to inflammation or infection.

Signs include:

• Pain in the upper right abdomen, often after a fatty meal

• Nausea or vomiting

• Fever or chills

• Yellowing of the skin or eyes (jaundice)

In some cases, gallbladder removal surgery may be necessary. If you have a history of gallbladder issues or experience these symptoms, talk to your healthcare provider promptly.

3. Worsening Diabetic Eye Disease

Ozempic may cause a temporary worsening of diabetic retinopathy, especially in people who already have eye complications from diabetes.

Watch for:

• Blurry or distorted vision

• Sudden loss of vision

• Floating spots or "floaters" in your vision

A 2017 study published in The New England Journal of Medicine found a higher incidence of diabetic retinopathy complications in some patients taking semaglutide. If you notice visual changes, don’t wait see an eye specialist immediately.

4. Kidney Damage

Ozempic may contribute to kidney problems, especially if you're dehydrated due to side effects like vomiting or diarrhea. This is particularly concerning for people who already have reduced kidney function.

Possible signs of kidney stress include:

• Swelling in the feet, ankles, or legs

• Confusion or mental fog

• Reduced urine output

• Unusual fatigue or weakness

Mild dehydration can quickly worsen kidney health, especially in people with diabetes. Stay well-hydrated, and report any of these symptoms to your provider.

5. Risk of Thyroid Cancer

Animal studies have shown a possible link between Ozempic and medullary thyroid carcinoma, a rare type of thyroid cancer. Although this hasn’t been proven in humans, the FDA has issued a boxed warning, the most serious type of warning for medications.

You should avoid Ozempic if you:

• Have a personal or family history of thyroid cancer

• Have a condition called multiple endocrine neoplasia syndrome type 2 (MEN 2)

Possible warning signs of thyroid cancer:

• A lump or swelling in your neck

• Hoarseness or voice changes

• Trouble swallowing or persistent sore throat

Speak with your provider before starting Ozempic if thyroid conditions run in your family.

Final Thoughts

Ozempic can offer powerful benefits for managing blood sugar and supporting weight loss but it’s not without risks. Awareness is key. Whether you're already taking it or considering it, pay attention to how your body responds and keep your healthcare team in the loop.

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